The use of probenecid as a chemoprotector against cisplatin nephrotoxicity
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چکیده
منابع مشابه
Renoprotective effects of antioxidants against cisplatin nephrotoxicity
Nephrotoxicity is the major limitation for the clinical use of cisplatin as an anti-tumoural drug. Intracellular effects of cisplatin cause tubular damage and tubular dysfunction with sodium, potassium, and magnesium wasting. Renoperotective strategies against cisplatin are classified on 8 targets: 1) Decrease of cisplatin uptake by renal cell, 2) Inhibition of cisplatin metabolism, 3) Blocking...
متن کاملEffect of infliximab against cisplatin-induced nephrotoxicity
OBJECTIVES To investigate whether infliximab (Ib), an inhibitor of tumor necrosis factor alpha (TNF-α), prevents cisplatin (Cis)-induced nephrotoxicity. METHODS The study was performed in the Department of Internal Medicine, Recep Tayyip Erdogan University, Rize, Turkey, between November 2012 and May 2013. Thirty male Wistar albino rats were divided into 3 groups, a control group, a Cis group...
متن کاملThe protective effect of Nigella sativa against cisplatin-induced nephrotoxicity in rats
Objective: The clinical use of cisplatin is highly restricted, because of its nephrotoxicity.In this study the protective effect of Nigella sativa (N. sativa) against cisplatin-induced nephrotoxicity was investigated in rats. Materials and Methods: In the current study, the effects of the administration of aqueous-ethanolic extract of N. sativa (100 and 200 mg/kg, BW) and vitamin E (100 mg/kg, ...
متن کاملThe Nephrotoxicity of Cisplatin
Cisplatin is a cancer chemotherapeutic agent whose cl inical use is complicated by i ts dose related kidney toxicity. Since the histopathological profi le of cisplatin nephrotoxicity appears similar to that of other heavy metals, i t has been commonly presumed that cisplatin nephrotoxicity is related to the platinum moiety. However, the delayed time course and development of cisplatin nephrotox...
متن کاملCisplatin nephrotoxicity: a review.
BACKGROUND Cisplatin is a major antineoplastic drug for the treatment of solid tumors, but it has dose-dependent renal toxicity. METHODS We reviewed clinical and experimental literature on cisplatin nephrotoxicity to identify new information on the mechanism of injury and potential approaches to prevention and/or treatment. RESULTS Unbound cisplatin is freely filtered at the glomerulus and ...
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ژورنال
عنوان ژورنال: Cancer
سال: 1991
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19910315)67:6<1518::aid-cncr2820670610>3.0.co;2-3